Welcome to Department of @ NIT, Manipur

Research at the Department of Chemistry

Inorganic and Medicinal Inorganic Chemistry

The primary research in this area is to explore the photo-activated electronic states of the transition metal complexes for photo-activated chemotherapeutic applications.

1. A red light-activable MnI(CO)3-functionalized gold nanocomposite as the anticancer prodrug with theranostic potential

Dulal Musib, Md Kausar Raza, Mrityunjoy Pal, Mithun Roy, Applied Organometallic ChemistryYear 2020, DOI:10.1002/aoc.6110  

2. Photo-physical, theoretical and photo-cytotoxic evaluation of a new class of curcumin based Lanthanium(III) complexes for PDT application

Dulal Musib, Mrityunjoy Pal, Md Kausar Raza and Mithun Roy, Dalton Trans. 2020, DOI:10.1039/D0DT02082F  

3. Nucleus targeting anthraquinone-based copper (II) complexes as the potent PDT agents: Synthesis, photo-physical and theoretical evaluation

Longjam Reena Devi, Md Kausar Raza, Dulal Musib, Vanitha Ramu, Joshila Devi, Mithun Roy, Inorg. Chim. Acta, 2020, DOI:10.1016/j.ica.2019.119208  

4. Potent anticancer activity of photo-activated oxo-bridged diiron(III) complexes

S. Binita Chanu, Samya Banerjee, Mithun Roy, Eur. J. Med. Chem., 2017, DOI:10.1016/j.ejmech.2016.09.090  

In silico and in vitro investigations of transition metal complexes as the potential inhibitors for SARS-CoV-2.

1. Transition metal complexes as the potential tools against SARS-CoV-2: In silico approach

Maynak Pal, Dulal Musib, Mithun Roy, New J. Chem., 2020, DOI:10.1039/D0NJ04578K  


Organo-synthesis and catalysis

Research in this area is the development of novel greener methods for organic synthesis. In this regard, a number of methods such as domino reactions, multicomponent reactions, transition metal catalysed reactions, organocatalysis and catalysis using efficient materials have extensively been explored. The research mainly focus on homogeneous catalysis of C-H activation transformed into C-C bonds.

Researcher also aims in devicing a novel and modular methodology to develop a range of DNA-based catalyst in which catalytic unit in the form of transition metal complex could be covalently anchored into the chiral DNA. Next step would be the application of those chiral catalyst for various asymmetric organic transformation.

1.  An organocatalytic C-C bond cleavage approach: A metal-free and peroxide-free facile method for the synthesis of amide derivatives, C. C. Malakar etal. New J. Chem., 2020, DOI:10.1039/d0nj04158k  

2. A Facile C-H Insertion Strategy using Combination of HFIP and Isocyanides: Metal-Free Access to Azole Derivatives, C. C. malakar etal., Asian J. Org. Chem., 2020, DOI:10.1002/ajoc.202000481  

3. Comprehensive Strategies for the Synthesis of Isoquinolines: Progress Since 2008, C. C. Malakar etal., Adv. Synth. Catl., 2020, DOI:10.1002/adsc.202000658 

4. Pd-Catalyzed Decarboxylation and Dual C(sp3)-H Functionalization Protocols for the Synthesis of 2,4-Diarylpyridines, C. C. Malakar etal., J Org. Chem., 2019, DOI:10.1021/acs.joc.8b02971  

Solidstate and Nano-Chemistry

The research in this area is to develop greener methods for the preparation of various nanoparticles.

1. Multicolour tuning of different RE ion doped CaMoO4 nanoparticles by single wavelength excitation, Th. David Singh etal., Journal of Materials Science: Materials in Electronics, 2020, DOI:10.1007/s10854-020-03493-6  

2. Synthesis, Characterization, Optical and Electrical Properties of Citrate Mediated Terbium Doped ZnO Nanoparticles for Multifunctional Applications, Th. David Singh etal., Integrated Ferroelectrics, 2020, DOI:10.1080/10584587.2019.1674976  


Solid-State Chemisttry


Key Publications:

S. Binita Chanu, Samya Banerjee, Mithun Roy* "Potent anticancer activity of photo-activated oxo-bridged diiron(III) complexes" Eur. J. Med. Chem.2017, 125, 816-824. 

N. Vodnala, D. Kaldhi, R. Gupta, S. Polina, V.P. R. K. Putta, S. C. P. Promily, R. K. Linthoinganbi, V. Singh, C. C. Malakar     “Novel Domino Routes for the Synthesis of N-Heterocycles via Reductive Cyclization of β-(N-2-Nitroaryl)-α,β-unsaturated Ketones”ChemistrySelect 2016, 1, 5784 – 5788.

N. Vodnala, D. Kaldhi, S. Polina, V.P. R. K. Putta, R. Gupta, S. C. P. Promily, R. K. Linthoinganbi, V. Singh, C. C. Malakar         “Pd-Catalyzed Domino Reactions of Nitroaromatics: A Surrogate Access towards the Saturated N-heterocycles” Tetrahedron Lett.2016, 57, 5695 – 5699.