Research at the Department of Chemistry
Inorganic and Medicinal Inorganic Chemistry
The primary research in this area is to explore the photo-activated electronic states of the transition metal complexes for photo-activated chemotherapeutic applications.
1. A red light-activable MnI(CO)3-functionalized gold nanocomposite as the anticancer prodrug with theranostic potential
Dulal Musib, Md Kausar Raza, Mrityunjoy Pal, Mithun Roy, Applied Organometallic Chemistry, Year2020, DOI:10.1002/aoc.6110
2. Photo-physical, theoretical and photo-cytotoxic evaluation of a new class of curcumin based Lanthanium(III) complexes for PDT application
Dulal Musib, Mrityunjoy Pal, Md Kausar Raza and Mithun Roy, Dalton Trans. 2020, DOI:10.1039/D0DT02082F
3. Nucleus targeting anthraquinone-based copper (II) complexes as the potent PDT agents: Synthesis, photo-physical and theoretical evaluation
Longjam Reena Devi, Md Kausar Raza, Dulal Musib, Vanitha Ramu, Joshila Devi, Mithun Roy, Inorg. Chim. Acta, 2020, DOI:10.1016/j.ica.2019.119208
4. Potent anticancer activity of photo-activated oxo-bridged diiron(III) complexes
S. Binita Chanu, Samya Banerjee, Mithun Roy, Eur. J. Med. Chem., 2017, DOI:10.1016/j.ejmech.2016.09.090
In silico and in vitro investigations of transition metal complexes as the potential inhibitors for SARS-CoV-2.
1. Transition metal complexes as the potential tools against SARS-CoV-2: In silico approach
Maynak Pal, Dulal Musib, Mithun Roy, New J. Chem., 2020, DOI:10.1039/D0NJ04578K&
Organo-synthesis and catalysis
Research in this area is the development of novel greener methods for organic synthesis. In this regard, a number of methods such as domino reactions, multicomponent reactions, transition metal catalysed reactions, organocatalysis and catalysis using efficient materials have extensively been explored. The research mainly focus on homogeneous catalysis of C-H activation transformed into C-C bonds.
Researcher also aims in devicing a novel and modular methodology to develop a range of DNA-based catalyst in which catalytic unit in the form of transition metal complex could be covalently anchored into the chiral DNA. Next step would be the application of those chiral catalyst for various asymmetric organic transformation.
1. An organocatalytic C-C bond cleavage approach: A metal-free and peroxide-free facile method for the synthesis of amide derivatives, C. C. Malakar etal. New J. Chem., 2020, DOI:10.1039/d0nj04158k
2. A Facile C-H Insertion Strategy using Combination of HFIP and Isocyanides: Metal-Free Access to Azole Derivatives, C. C. malakar etal., Asian J. Org. Chem., 2020, DOI:10.1002/ajoc.202000481
3. Comprehensive Strategies for the Synthesis of Isoquinolines: Progress Since 2008, C. C. Malakar etal., Adv. Synth. Catl., 2020, DOI:10.1002/adsc.202000658
4. Pd-Catalyzed Decarboxylation and Dual C(sp3)-H Functionalization Protocols for the Synthesis of 2,4-Diarylpyridines, C. C. Malakar etal., J Org. Chem., 2019, DOI:10.1021/acs.joc.8b02971
Solidstate and Nano-Chemistry
The research in this area is to develop greener methods for the preparation of various nanoparticles.
1. Multicolour tuning of different RE ion doped CaMoO4 nanoparticles by single wavelength excitation, Th. David Singh etal., Journal of Materials Science: Materials in Electronics, 2020 DOI:10.1007/s10854-020-03493-6
2. Synthesis, Characterization, Optical and Electrical Properties of Citrate Mediated Terbium Doped ZnO Nanoparticles for Multifunctional Applications, Th. David Singh etal., Integrated Ferroelectrics, 2020, DOI:10.1080/10584587.2019.1674976
S. Binita Chanu, Samya Banerjee, Mithun Roy*"Potent anticancer activity of photo-activated oxo-bridged diiron(III) complexes" Eur. J. Med. Chem, 2017, 125, 816-824.
N. Vodnala, D. Kaldhi, R. Gupta, S. Polina, V.P. R. K. Putta, S. C. P. Promily, R. K. Linthoinganbi, V. Singh, C. C. Malakar “Novel Domino Routes for the Synthesis of N-Heterocycles via Reductive Cyclization of β-(N-2-Nitroaryl)-α,β-unsaturated Ketones”ChemistrySelect2016,1, 5784 – 5788.
N. Vodnala, D. Kaldhi, S. Polina, V.P. R. K. Putta, R. Gupta, S. C. P. Promily, R. K. Linthoinganbi, V. Singh, C. C. Malakar “Pd-Catalyzed Domino Reactions of Nitroaromatics: A Surrogate Access towards the Saturated N-heterocycles” Tetrahedron Lett., 2016, 57, 5695 – 5699.